Tk6 lymphoblastoid cell

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August undefined, 2024

WebWe studied the genotoxicity of ethyl carbamate in Salmonella typhimurium, in Saccharomyces cerevisiae and in human lymphoblastoid TK6 cells. In absence of cytochrome P450 enzymes, no ethyl carbamate-mediated genotoxicity was observed in any of the three test systems in the non-cytotoxic range. In the presence of an activating … WebJialong Chen is an academic researcher from Southern Medical University. The author has contributed to research in topic(s): DNA methylation & Trichostatin A. The author has an hindex of 4, co-authored 7 publication(s) receiving 38 citation(s).

Jialong Chen Southern Medical University 7 Publications 38 ...

WebTk6 Human Lymphoblastoid Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, … WebMar 11, 2024 · The human lymphoblastoid TK6 cell line was established in 1978 from the parent cell line WI-L2 that was derived from a 5-year-old male with hereditary spherocytosis (Lorge et al., 2016). Due to TK heterozygosity on human chromosome 17 in these cells as well as the presence of the hypoxanthine phosphoribosyltransferase ( HPRT ) gene on the … earth vegetarian

Development and Application of TK6-derived Cells

WebFor TK6 assay: The TK6 is a human lymphoblastoid cell line. The parent cell line is an Epstein-Barr virus-transformed cell line, WI-L2, which was originally derived from a 5-year … Webthe human TK6 lymphoblastoid cell line (35), HepG2 cells (36) (37) and primary Syrian Hamster Embryo cells (38) has been described, although they have not been used in validation studies. ... cells analysed are likely to have undergone cell division during or after exposure to the test substance. For WebTK6 is a lymphoblast cell line that was isolated from the spleen of a 5-year-old, male with hereditary spherocytosis. The cells are heterozygous at the thymidine kinase (TK) locus … earth vellumental collectibles paper mario

Induction of micronuclei by four cytostatic compounds in human …

Tk6 lymphoblastoid cell

OECD GUIDELINE FOR THE TESTING OF CHEMICALS

WebJun 1, 2024 · TK6 cells, which are grown in suspension, are also one of the most frequently used cell lines for the in vitro chromosome aberration, MN, and comet assays. Recent whole-genome sequencing indicated negligible variability between TK6 and the human … WebFeb 20, 2024 · Here, TK6 cells exhibited 17.2 ± 4.5 micronucleated cells per 1,000 binucleated cells. HSC showed a lower frequency of 5.5 ± 2.8 micronucleated cells per 1,000 binucleated cells...

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WebAug 1, 1995 · TK6 is a human cell line developed for gene mutation assays and thus may have advantages for human hazard identification and assessment. On the other hand, L5178Y, a mouse cell line, is a widely used gene mutation assay system, and its large database is helpful when assessing chemical genotoxicity and comparing magnitudes of … WebJan 17, 2024 · The TK6 cell line with wild type p53 function was used in our experiments. TK6 cells (human lymphoblastoid cells from spleen) were originally provided by the Tumorbank of the German Cancer Research Center, DKFZ, Heidelberg, Germany. DNA cell line authentication was done by Eurofins Medigenomix Forensik GmbH, Ebersberg, …

WebThe TK6 Micronucleus Assay is ideal for use as a follow up assay to explore mechanism of action (aneugenic or clastogenic) from an initial positive genotoxicity result. In a TK6 MN … WebA comparative study of TK6 human lymphoblastoid and L5178Y mouse lymphoma cell lines in the in vitro micronucleus test. Micronucleus induction was compared in human …

WebTCL6. In molecular biology, T-cell leukemia/lymphoma 6 (non-protein coding), also known as TCL6 is a long non-coding RNA. It is expressed in T-cell leukemia with a t (14;14) … WebMar 19, 2007 · Relative mutagenic potencies of several nucleoside analogs, alone or in drug pairs, at the HPRT and TK loci of human TK6 lymphoblastoid cells - Carter - 2007 - Environmental and Molecular Mutagenesis - Wiley Online Library Environmental and Molecular Mutagenesis Research Article

WebAug 1, 1995 · TK6 is a human cell line developed for gene mutation assays and thus may have advantages for human hazard identification and assessment. On the other hand, …

WebATCC human lymphoblastoid tk6 cell line 94 1 9.99 to $1999.99 human lymphoblastoid tk6 cell line - by Bioz Stars , 2024-03 94 / 100 stars Images human tk6 lymphoblastoid cells ( ATCC ) ATCC is a verified supplier ATCC manufactures this product About News Press Release Team Advisors Partners Contact Bioz Stars Bioz vStars Buy from Supplier Images ctrl what to deleteWebTK6 human lymphoblastoid cells are widely used in the in vitro MN assay as a part of regulatory genotoxicity testing for pharmaceuticals, but have seen relatively limited use … ctrl what for pasteWebJan 1, 2016 · Abstract Closely related TK6, WTK1, and NH32 human B-lymphoblastoid cell lines differ in their p53 functional status. These lines are used frequently in genotoxicity studies and in studies aimed at understanding the role of p53 in DNA repair. Despite their routine use, little is known about the genetic status of these cells. earth vellumental guideWebFeb 9, 2024 · Lymphoblastoid TK6 cells were treated with the genotoxins (GTX) aflatoxin B1 (AB1), benzo [ a ]pyrene (BaP), lasiocarpine (Las), methyleugenol (ME), or N-nitrosopyrrolidine (NPYR) or with non-genotoxins (NGTX) 3-monochloropropane-1,2-diol (3-MCPD), methapyrilene (MPH), perfluorooctanoic acid (PFOA), or perfluorooctanesulfonic … ctrlwidgetWebCell Line Description. The thymidine kinase heterozygote cell line TK6 has been isolated from the lymphoblastoid line HH4. HH4 was derived from the WIL-2 cell line. TK6 cells are … ctrl when pressing gshiftWebThe thymidine kinase heterozygote cell line TK6 has been isolated from the lymphoblastoid line HH4. HH4 was derived from the WIL-2 cell line. TK6 cells are CD19 positive, 50% of the cell population express CD20 and a small sub-population has been tested positive for CD22. We cannot confirm the BVDV status of this cell line. ctrl w functionWebJul 4, 2012 · Abstract. The Organization for Economic Co-operation and Development (OECD) has recently adopted Test Guideline 487 (TG487) for conducting the in vitro micronucleus (MNvit) assay. The purpose of this study is to evaluate and validate treatment conditions for the use of p53 competent TK6 human lymphoblastoid cells in a TG487 … earth vellumental stones