Shoc2蛋白

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August undefined, 2024

WebLeucine-rich repeat (LRR) protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene. The best-studied role of SHOC2 is in modulating signals of the extracellular … Web13 Jul 2024 · The SHOC2–MRAS–PP1C holophosphatase complex functions as a key regulator of RTK–RAS signalling by removing an inhibitory phosphorylation event on the …

SHOC2 (D7N1A) Rabbit mAb Cell Signaling Technology

Web8 Jul 2024 · The authors identified a heterozygous mutation (S2G; 602775.0001) in the SHOC2 gene in 4 unrelated individuals. They then analyzed the SHOC2 gene in a cohort of … Web订购Sur-8 抗体，可应用于免疫印迹,免疫组化检测，可与人,小鼠,大鼠样本反应，预测反应种属猪,斑马鱼,牛,马,羊,兔,狗,爪蟾，国内现货。 names of japan doctors on instagram

Structure–function analysis of the SHOC2–MRAS–PP1C …

Web13 Jul 2024 · A structure of the MRAS–SHOC2–PP1C complex supports a RAS-driven and multi-molecular model for RAF activation in which individual RAS–GTP molecules recruit RAF–14-3-3 and SHOC2–PP1C to ... WebA key phosphatase that mediates this dephosphorylation step is a heterotrimeric complex composed of MRAS, SHOC2, and protein phosphatase 1 (PP1) ().SHOC2 is a ubiquitously expressed protein composed almost exclusively of leucine-rich repeats (LRRs) that was originally identified in Caenorhabditis elegans as a positive modulator of the ERK pathway … Web21 Jun 2013 · Shoc2 is a positive regulator of signaling to extracellular signal-regulated protein kinases 1 and 2 (ERK1/2). Shoc2 is also proposed to interact with RAS and Raf-1 in order to accelerate ERK1/2 activity. To understand the mechanisms by which Shoc2 regulates ERK1/2 activation by the epidermal growth factor receptor (EGFR), we dissected … megabowl merthyr

SHOC2 phosphatase-dependent RAF dimerization mediates

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Web4 Feb 2024 · DOI: 10.1038/s41594-022-00841-4. Primary Citation of Related Structures: 7TVF, 7TVG. PubMed Abstract: SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by ... Web采集先证者及其父母外周血，提取基因组dna行全外显子组测序，结果显示，先证者shoc2基因2号外显子存在c.4a>g错义突变，导致第2号氨基酸由丝氨酸变为甘氨酸（p.s2g），患儿父母未检出该突变。结合临床表型与基因突变，确诊为努南样综合征伴生长期毛发松动。 megabowl gloucesterWeb27 Jul 2024 · Based on a systems biology approach that identified SHOC2 as a candidate gene, Cordeddu et al. (2009) sequenced SHOC2 coding exons in a Noonan syndrome cohort that included 96 individuals who were negative for mutations in known disease genes and identified a heterozygous mutation (S2G; 602775.0001) in 4 unrelated individuals.They … names of jackson five

"Web29 Sep 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating ... " - Shoc2蛋白

Shoc2蛋白

NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR …

Web10 Jun 2024 · The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-ERK pathway activation by dephosphorylating a critical inhibitory site on RAF kinases. Here we show that genetic inhibition of SHOC2 suppresses tumorigenic growth in a subset of KRAS-mutant NSCLC cell lines and prominently inhibits tumour development in … Web20 Jun 2001 · Function. Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS …

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Web丁香通为您提供IL34Antibody商品详情介绍：价格：询价，货号：LBP70500，品牌：Leading Biology，产地：美国，详见丁香通IL34Antibody商品详情页； Web7 Aug 2024 · This dephosphorylation relies on a multi-subunit phosphatase, known as the SHOC2 phosphatase complex. Inhibiting SHOC2, the researchers hypothesised, could …

Web10 May 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases. Here we present the high … Web29 Jun 2024 · shoc2是一个重要的支架蛋白，它与pp1c和ras一起参与raf ntps11的去磷酸化，但shoc2的结构和推定的shoc2-pp1c-ras复合物的结构仍然未知。

Web24 Feb 2024 · 在人细胞中，SHOC2是一种加速ERK1/2信号转导的支架蛋白，而从寄生虫到哺乳动物，SHOC2均高度保守。基于此，研究者进一步探讨，Erk是否参 … Web10 Jun 2024 · SHOC2 inhibition perturbs tumour growth in lung cancer models. To study the in vivo role of SHOC2 we have developed two mouse models of SHOC2 inactivation using Knock-out (KO) or Knock-in (KI ...

Web10 May 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and …

WebSrc Homolgy-2磷酸酶(SHP2)是PTPN11基因所编码的非受体蛋白酪氨酸磷酸酶，其促进多种细胞功能，包括增殖、分化、细胞周期维持和迁移。 SHP2牵涉在经由Ras-有丝分裂原-激活的蛋白激酶、JAK–STAT或磷酸肌醇3-激酶-AKT途径的信号传导中。 megabowl liverpool switch islandWeb13 Jul 2024 · The researchers found that when they deleted the SHOC2 gene or decreased its expression, the MEK inhibitors were highly effective at eliminating cancer cells, revealing SHOC2 as a culprit in resistance to MEK inhibitors. Protein puzzle. The team decided to further study SHOC2 as a potential target, which included solving its structure. megabowl newportWebSHOC2. （SHOC2 leucine rich repeat scaffold protein）. 这个基因编码一种几乎完全由富含亮氨酸重复序列组成的蛋白质，这是一个与蛋白质相互作用有关的结构域在RAS/ERK … megabowl longfordWeb5 Nov 2024 · Studies over the past decade have uncovered the critical role of the Shoc2 scaffold in the transmission of signals through the core ERK1/2 cascade (Jang et al., 2024).These studies convincingly demonstrated that this seemingly auxiliary component of the ERK1/2 signaling network is an indispensable regulator of the ERK1/2 pathway, as its … megabowl newcastleWebSHOC2 has been shown to interact with the catalytic phosphatase subunit PP1C(PMID 16630891) and MRAS as well as canonical RAS isoforms (H/K/NRAS)(PMID 35768504, 35831509, 35830882). The ternary complex SHOC2-RAS-PP1C functions to dephosphorylate an inhibitory phosphorylation site ('S259') on RAF family proteins to enable MAPK … names of james bond moviesWeb30 Sep 2010 · Mutation analysis in patients and development of a rapid mutation detection system. Sequence analysis of all coding regions of SHOC2 in 92 patients revealed a c.4A>G mutation (p.S2G) in exon1 of ... mega bowl parrs woodWeb3 Oct 2024 · This is achieved by PP1, whose specificity for RAF is conferred by the dual action of the scaffold protein SHOC2 and a second small GTPase, M-RAS. Four new structures, three published in Nature ... megabowl plymouth