Phosphonoformic acid
WebFeb 3, 2024 · FOS (phosphonoformic acid; PFA), which is structurally similar to the pyrophosphate anion, binds to the HCMV UL54 DNA polymerase and blocks the pyrophosphate-binding site, preventing the incorporation of incoming deoxynucleotide triphosphates (dNTPs) into viral DNA ( Chrisp and Clissold, 1991 ). WebSep 1, 2006 · Phosphonoformic acid is an pyrophosphate mimic that serves as an antiviral agent (Lindqvist and Nordstrom, 2001). Fosamine is an herbicide (Ware, 2000) and …
Phosphonoformic acid
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WebTrisodium phosphonoformate, known also as phosphonoformic acid (PFA) or foscarnet (Fig. 12.1), is a non-nucleoside inhibitor of the DNA polymerases of herpesviruses and hepatitis B, as well as the reverse transcriptase of HIV. It acts through a non-competitive inhibition of the pyrophosphate-binding site on the enzyme. WebJul 15, 2011 · Phosphonoformic acid (PFA or foscarnet; Fig. 1) is a broad spectrum antiviral mimicking the pyrophosphate (PP i) leaving group of the nucleotide transfer reaction.For the treatment of HCMV, PFA provides alternative inhibition of UL54 in second line regimens after accumulated resistance compromises nucleoside analog-based therapies.
WebJul 15, 2011 · Phosphonoformic acid (PFA, foscarnet) belongs to a class of antiviral drugs that inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the … WebOct 22, 2009 · Phosphonoformic acid (PFA, foscarnet) belongs to a class of antiviral drugs that inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction. Difficulties expressing UL54 have hampered investigation of the precise structural requirements rendering …
Webphosphonoformic acid ( CHEBI:127780 ) has role sodium-dependent Pi-transporter inhibitor ( CHEBI:63330 ) phosphonoformic acid ( CHEBI:127780 ) is a carboxylic acid ( … WebThe activity of phosphonoacetic acid (PAA) and phosphonoformic acid (PFA) against four strains of herpes simplex virus type 1 (HSV-1) and four strains of HSV-2 were compared in …
WebSynthesis of esters of phosphonoformic acid and their antiherpes activity Aliphatic and aromatic mono-, di-, and triesters of phosphonoformic acid (foscarnet) were synthesized. …
WebSodium phosphonoformate tribasic hexahydrate Synonym (s): Foscarnet, Phosphonoformic acid trisodium salt hexahydrate Linear Formula: Na2O3PCO2Na · 6H2O CAS No.: 34156-56-4 Molecular Weight: 300.04 Match Criteria: Product Name, Keyword All Photos ( 1) Foscarnet impurity D Synonym (s): Triethyl phosphonoformate, Ethyl diethoxyphospinylformate can change form and move matterWebJul 15, 2011 · Phosphonoformic acid (PFA or foscarnet; Fig. 1) is a broad spectrum antiviral mimicking the pyrophosphate (PP i) leaving group of the nucleotide transfer reaction. For … fishing wheelchairWebCAS NO: 63585-09-1 纯 度: 99% 规 格: 桶装kg 价 格: 洽谈 马上询价 fishing wheelbarrows for saleWebSep 4, 1989 · Effect of phosphonoformic acid, dietary phosphate and the Hyp mutation on kinetically distinct phosphate transport processes in mouse kidney We examined the … fishing what is a wafterWeb2007-06-29. CMP-5 '- phosphonoformic acid is a cytidine 5'-phosphate obtained by formal condensation of the phosphate group of CMP with the phosphono group of … fishing wheelbarrowWebAll Products_BioChemPartner. Phone:0086-13720134139 0086-15971444841. Signaling Pathways. Angiogenesis/Protein Tyrosine Kinase fishing wheeler branchWeb$265.00 Foscarnet Sodium (50 mg) (Phosphonoformic acid, trisodium salt, hexahydrate) Catalog No: 1283302 CAS RN ® 34156-56-4 Molecular Formula: CNa3O5P . 6H2O Product Type: Reference Standard Add to Cart star Add to Favorites Shipping Information Current Lot Information Current Lot: R142G0 CAS RN® 34156-56-4 Harmonized System (HS) Code *: … fishing wheeler dam