Phospholipase a2 gene
WebSullivan CP, Seidl SE, Rich CB et al Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. J Biol Chem 285:565–575 WebMar 28, 2024 · In a Serbian brother and sister with GURDP, Brooke et al. (2014) identified a homozygous 4-bp deletion in the PLA2G4A gene ( 600522.0004 ). The mutation, which …
Phospholipase a2 gene
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WebPLA2G7 phospholipase A2 group VII [ (human)] Gene ID: 7941, updated on 5-Aug-2024 Summary The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. WebDec 18, 2024 · Phospholipase A2 group VI (PLA2G6)-associated neurodegeneration (PLAN) includes a series of neurodegenerative diseases that result from the mutations in PLA2G6. PLAN has genetic and clinical heterogeneity, with different mutation sites, mutation types and ethnicities and its clinical phenotype is different.
WebCytosolic phospholipase A2α gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis WebPHOSPHOLIPASE A2 (PLA2) ENZYME PREPARATION FROM STREPTOMYCES VIOLACEORUBER EXPRESSING A GENE ENCODING PLA2 FROM S. VIOLACEORUBER …
WebMar 28, 2024 · PLA2B, the synovial phospholipase A2 described by Seilhamer et al. (1989), is a small molecular weight enzyme that is DTT-sensitive. PLA2B is secreted from cells, active in the micromolar to millimolar calcium concentration range that prevails in the extracellular medium, and active in inflammatory exudates. WebHas phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid ( By similarity ). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion ( By similarity ).
WebMay 12, 2024 · Ma, Z., Wang, X., Nowatzke, W., Ramanadham, S., Turk, J. Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group …
WebNov 16, 2015 · Astrocytic phospholipase A2 contributes to neuronal glutamate toxicity.pdf 2015-11-16 上传 Astrocytic phospholipase A2 contributes to neuronal glutamate toxicity granite falls fireWebDisruption of the phospholipase PLA2-3 gene could effectively improve lipid production in Y. lipolytica. Significance and impact of the study: This study presented a strategy on … chinmay mission bhopalWebCytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:109,709,989-109,730,070 (from NCBI) TEXT Description Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. chinmay mittal codeforcesWebCadmium is a heavy metal that is known to cause toxicity to cells and, at low concentrations, can initiate apoptosis. This study was undertaken with the aim of defining the role of phospholipase C (P granite falls fire callsWebMar 13, 2024 · In this study, the function of the patatin-like phospholipase gene in V. dahliae (VdPLP, VDAG_00942) is characterized by generating gene knockout and complementary mutants. ... Percudani, R.; Bonfante, P.; Ottonello, S. A nutrient-regulated, dual localization phospholipase A2 in the symbiotic fungus Tuber borchii. EMBO J. 2001, 20, 5079–5090 ... granite falls fire samanthaWebThis gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. chinmay mehtaWebSep 13, 2024 · To this regard, various host phospholipase A2 enzymes have been described to specifically cleave and remove peroxidised phospholipids from membranes [60–62]. To address this hypothesis, we performed a redox phospholipidomic approach to determine if ExoU could interfere with the endogenous levels of peroxidised phospholipids ( Figs … chinmay mhatre