WebHowever, OR2AT4 silencing significantly enhanced both HF KC apoptosis and TGFβ2 expression. This supports that OR-mediated signalling regulates human HF KC biology in situ and suggests that OR2AT4 stimulation by (as yet unknown) endogenous ligands is required to down-regulate KC apoptosis and TGFβ2 expression in human anagen HFs.
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WebNov 1, 2014 · In this study, we concentrated on OR2AT4 for functional characterization and deorphanization because we could express this OR as a rhodopsin-tagged construct (Krautwurst et al., 1998; Wetzel et al., 1999) in Hana3A cells (Saito et al., 2004), a HEK293T-derived cell line that stably expresses RTP1L, RTP2, REEP1, and Gα olf, and supports the … WebJul 9, 2024 · In a randomized, double-blinded, placebo-controlled, clinical trial, 60 female volunteers (18-65 years) affected by telogen effluvium received over a period of 24 weeks treatment with either 1% Sandalore ® solution (n = 30) or placebo (identically smelling, but non-OR2AT4 activating sandalwood oil n = 30). The study read-out parameters were ...
WebSep 22, 2024 · OR2AT4 olfactory receptor family 2 subfamily AT member 4 Gene ID: 341152, updated on 22-Sep-2024 Gene type: protein coding Also known as: OR11-265. See all … WebSandalore is a synthetic sandalwood odorant [1] [2] with odor in some ways similar to sandalwood and consequently used in perfumes, emollients, and skin cleaning agents. Sandalore, and the similar brahmanol, have been identified as agonists of the cutaneous olfactory receptor OR2AT4, and found to induce strong Ca 2+ signals in cultured human ...
WebJul 7, 2014 · A Synthetic Sandalwood Odorant Induces Wound-Healing Processes in Human Keratinocytes via the Olfactory Receptor OR2AT4 Daniela Busse1, Philipp Kudella1,Nana-MariaGru¨ning1,7,Gu¨nter Gisselmann1, Sonja Sta¨nder2, Thomas Luger3,FrankJacobsen4, Lars Steinstra¨ er4,8,RalfPaus5, Paraskevi Gkogkolou6, Markus Bo¨hm6, Hanns Hatt1 and … WebSep 18, 2024 · OR2AT4 mRNA and protein expression in human scalp epidermis and hair follicles in situ. a Representative pictures of OR2AT4 immunofluorescence in human …
WebActivation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes 7. Stimulation of OR2AT4 by sandalore promotes hair …
WebJan 1, 2024 · Overexpression of another ectopic OR OR2AT4, β2-adrenergic receptor, or treatment of cells with forskolin did not suppress cell proliferation, indicating that a rise in cAMP is not sufficient to induce cytostasis. Overexpression of OR51E1 caused an upregulation of cytostatic and cell death markers including p27, p21, and p53, strongly ... income property tax benefitsWebOR2AT4 INFORMATION. Proteini. Full gene name according to HGNC. Olfactory receptor family 2 subfamily AT member 4. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. OR2AT4. Protein classi. Assigned HPA protein class (es) for the encoded protein (s). inception curently streamingWebNov 3, 2024 · OR2AT4 was functionally expressed in human keratinocytes (HaCaT) and exhibited co-expression with G-protein-coupled receptor signaling components, Golfα and … income protection advisorsWebOdorant receptor. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor … inception dalkeith palaceWebDec 12, 2024 · The estimated sizes of OR2AT4, OR1A2, or OR1A1 were 400, 212, or 670 bp (n = 3). OR2AT4 (D) and OR1A2 (E) proteins were detected by Western blot (n = 2–3). The estimated size of both OR2AT4 and OR1A2 was 34 kDa (arrows). F, G Intracellular localization of OR2AT4 and OR1A2 (each in red) by immunocytochemistry (n = 3). The … inception datasetWebJun 16, 2024 · ヒトでは398種類の嗅覚センサーが存在するが、その中のOR2AT4とOR51B5は白檀のにおいを感知することが皮膚でも報告されており、皮膚細胞の増殖や ... inception cz onlineWebNov 3, 2024 · OR2AT4 was functionally expressed in human keratinocytes (HaCaT) and exhibited co-expression with G-protein-coupled receptor signaling components, Golfα and adenylate cyclase 3. inception dashboard