Cancer testis gene
WebJan 27, 2016 · Cancer-testis (CT) genes represent the similarity between the processes of spermatogenesis and tumorigenesis. It is possible that their selective expression pattern … WebBackground: Testicular cancer severely affects male health, so finding effective diagnosis and prognostic indicators and exploring its pathogenesis are very important. Purpose: This study aims to explore the hub genes that play important roles in the occurrence and development of testicular germ cell tumor (TGCT).
Cancer testis gene
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WebMar 15, 2007 · Abstract. Purpose: Cancer/testis (CT) genes predominantly expressed in the testis (germ cells) and generally not in other normal tissues are aberrantly expressed in human cancers. This highly restricted expression provides a unique opportunity to use these CT genes for diagnostics, immunotherapeutic, or other targeted therapies. The purpose … WebMar 1, 2003 · Cancer/testis‐associated genes (CTAs) are a subgroup of tumor antigens with a restricted expression in testis and malignancies. During the last decade, many of these immunotherapy candidate genes have been discovered using various approaches. Most of these genes are localized on the X‐chromosome, often as multigene families.
WebNational Center for Biotechnology Information WebThe protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X …
WebApr 10, 2024 · The chemical complementarity of glioblastoma, tumor-resident T-cell receptors and cancer testis antigens were associated with a worse outcome. Additionally, the high expression of immune marker and low expression of apoptosis genes were associated with a high T-cell receptor–cancer testis antigen chemical complementarity … WebFeb 5, 2024 · A cancer/testis antigen (CTA) termed preferentially expressed antigen in melanoma (PRAME) that encodes the human leucocyte antigen (HLA)-A24 antigen was first characterized in 1997. 1 The PRAME gene is localized on the reverse strand of chromosome 22 (22q11.22), is approximately 12 kilobases long and contains leucine-rich …
WebApr 12, 2024 · TDRD1 (Tudor Domain Containing 1) is a germ cell-specific gene solely expressed in human testes and ovaries under physiological conditions but not in any …
WebCancer-testis (CT) genes are a group of genes restrictedly expressed in testis and multiple cancers and can serve as candidate driver genes participating in the … shannon hogan ziff davisWebApr 4, 2024 · A 2016 Nordic study found that the risk of genetic factors influencing the development of testicular cancer was 37%. An additional 24% risk was due to a shared … shannon holbertWebThe protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012] shannon hogan obituaryWebDec 1, 2024 · Cancer testis antigens (CTA) describe a group of proteins that are predominantly expressed in adult testes while silenced in most other somatic tissues [ 1, … shannon hogarthWebThe current hypothesis is that familial testicular cancer results from the combined effects of many genes, each of which by itself causes only a small increase in cancer risk. Those … shannon hogan ny islandersWebMay 8, 2024 · da Silva, V. L. et al. Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis. Oncotarget 8, 92966 (2024). shannon hoffpauirWebHere are some tips for preventing and reducing the risk of testicular cancer: Perform regular self-exams: Men should perform monthly self-exams to check for any lumps or abnormalities in their testicles. If any changes are noticed, they should see a doctor immediately. Maintain a healthy lifestyle: A healthy diet and regular exercise can help ... shannon holdeman